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- Title
First imported case of Candida auris infection in Milan, Italy: genomic characterisation.
- Authors
Rimoldi, Sara Giordana; Nodari, Riccardo; Rizzo, Alberto; Tamoni, Alessandro; Longobardi, Concetta; Pagani, Cristina; Grosso, Silvia; Salari, Federica; Galimberti, Laura; Olivieri, Pietro; Rizzardini, Giuliano; Catena, Emanuele; Antinori, Spinello; Comandatore, Francesco; Castelli, Antonio; Gismondo, Maria Rita
- Abstract
Purpose: Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance. Case presentation: On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain. Conclusion: Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.
- Subjects
ITALY; MYCOSES; CANDIDA; GENOMICS; HYPERTENSION; MULTIDRUG resistance; INTENSIVE care units; DIABETES; SEQUENCE analysis; PHENOTYPES
- Publication
Infection, 2024, Vol 52, Issue 4, p1633
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-024-02232-x