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- Title
Osteoinductive bone graft substitutes.
- Authors
Ludwig, Steven C.; Kowalski, Joseph M.; Boden, Scott D.; Ludwig, S C; Kowalski, J M; Boden, S D
- Abstract
This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.
- Subjects
BONE growth; CYTOKINES; GROWTH factors; CLINICAL trials; SKELETAL maturity; MEDICAL research; BONE morphogenetic proteins; BONE substitutes; BONE grafting; FORECASTING; RESEARCH; SPINAL fusion; OSSEOINTEGRATION
- Publication
European Spine Journal, 2000, Vol 9, pS119
- ISSN
0940-6719
- Publication type
journal article
- DOI
10.1007/PL00008317