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- Title
Early perfusion changes within 1 week of systemic treatment measured by dynamic contrast-enhanced MRI may predict survival in patients with advanced hepatocellular carcinoma.
- Authors
Chen, Bang-Bin; Hsu, Chao-Yu; Yu, Chih-Wei; Liang, Po-Chin; Hsu, Chiun; Hsu, Chih-Hung; Cheng, Ann-Lii; Shih, Tiffany; Shih, Tiffany Ting-Fang
- Abstract
<bold>Objectives: </bold>To correlate early changes in the parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) within 1 week of systemic therapy with overall survival (OS) in patients with advanced hepatocellular carcinoma (HCC).<bold>Methods: </bold>Eighty-nine patients with advanced HCC underwent DCE-MRI before and within 1 week following systemic therapy. The relative changes of six DCE-MRI parameters (Peak, Slope, AUC, Ktrans, Kep and Ve) of the tumours were correlated with OS using the Kaplan-Meier model and the double-sided log-rank test.<bold>Results: </bold>All patients died and the median survival was 174 days. Among the six DCE-MRI parameters, reductions in Peak, AUC, and Ktrans, were significantly correlated with one another. In addition, patients with a high Peak reduction following treatment had longer OS (P = 0.023) compared with those with a low Peak reduction. In multivariate analysis, a high Peak reduction was an independent favourable prognostic factor in all patients [hazard ratio (HR), 0.622; P = 0.038] after controlling for age, sex, treatment methods, tumour size and stage, and Eastern Cooperative Oncology Group performance status.<bold>Conclusions: </bold>Early perfusion changes within 1 week following systemic therapy measured by DCE-MRI may aid in the prediction of the clinical outcome in patients with advanced HCC.<bold>Key Points: </bold>• DCE-MRI is helpful to evaluate perfusion changes of HCC after systemic treatment. • Early perfusion changes within 1 week after treatment may predict overall survival. • High Peak reduction was an independent favourable prognostic factor after systemic treatment.
- Subjects
LIVER cancer; BIOMARKERS; CONTRAST-enhanced magnetic resonance imaging; PERFUSION; TREATMENT effectiveness; MAGNETIC resonance imaging
- Publication
European Radiology, 2017, Vol 27, Issue 7, p3069
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4670-2