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- Title
Non-invasive assessment of functionally relevant coronary artery stenoses with quantitative CT perfusion: preliminary clinical experiences.
- Authors
So A; Wisenberg G; Islam A; Amann J; Romano W; Brown J; Humen D; Jablonsky G; Li JY; Hsieh J; Lee TY; So, Aaron; Wisenberg, Gerald; Islam, Ali; Amann, Justin; Romano, Walter; Brown, James; Humen, Dennis; Jablonsky, George; Li, Jian-Ying
- Abstract
<bold>Objectives: </bold>We developed a quantitative Dynamic Contrast-Enhanced CT (DCE-CT) technique for measuring Myocardial Perfusion Reserve (MPR) and Volume Reserve (MVR) and studied their relationship with coronary stenosis.<bold>Methods: </bold>Twenty-six patients with Coronary Artery Disease (CAD) were recruited. Degree of stenosis in each coronary artery was classified from catheter-based angiograms as Non-Stenosed (NS, angiographically normal or mildly irregular), Moderately Stenosed (MS, 50-80% reduction in luminal diameter), Severely Stenosed (SS, >80%) and SS with Collaterals (SSC). DCE-CT at rest and after dipyridamole infusion was performed using 64-slice CT. Mid-diastolic heart images were corrected for beam hardening and analyzed using proprietary software to calculate Myocardial Blood Flow (MBF, in mL∙min(-1)∙100 g(-1)) and Blood Volume (MBV, in mL∙100 g(-1)) parametric maps. MPR and MVR in each coronary territory were calculated by dividing MBF and MBV after pharmacological stress by their respective baseline values.<bold>Results: </bold>MPR and MVR in MS and SS territories were significantly lower than those of NS territories (p < 0.05 for all). Logistic regression analysis identified MPR∙MVR as the best predictor of ≥50% coronary lesion than MPR or MVR alone.<bold>Conclusions: </bold>DCE-CT imaging with quantitative CT perfusion analysis could be useful for detecting coronary stenoses that are functionally significant.
- Publication
European Radiology, 2012, Vol 22, Issue 1, p39
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2260-x