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- Title
Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT.
- Authors
Fischer MA; Nanz D; Hany T; Reiner CS; Stolzmann P; Donati OF; Breitenstein S; Schneider P; Weishaupt D; von Schulthess GK; Scheffel H; Fischer, Michael A; Nanz, Daniel; Hany, Thomas; Reiner, Caecilia S; Stolzmann, Paul; Donati, Olivio F; Breitenstein, Stefan; Schneider, Paul; Weishaupt, Dominik
- Abstract
<bold>Objective: </bold>To prospectively evaluate the diagnostic accuracy of whole-body T2-weighted (wbT2), whole-body diffusion-weighted imaging (wbDWI) and wbT2/wbDWI image fusion for malignant tumour detection compared with PET/CT.<bold>Methods: </bold>Sixty-eight patients (44 men; 60 ± 14 years) underwent PET/CT for staging of malignancy and were consecutively examined by 1.5-Tesla MRI including wbT2 and wbDWI. Two radiologists independently assessed wbDWI, wbT2, wbT2 + wbDWI (side-by-side) and wbT2 + wbDWI + wbT2/wbDWI image fusion for the presence of malignancy. PET/CT served as a reference standard.<bold>Results: </bold>PET/CT revealed 374 malignant lesions in 48/64 (75%) patients. Detection rates and positive predictive value (PPV) of wbT2 and wbDWI alone were 64% and 84%, and 57% and 93%, respectively. Detection rates and PPV of wbT2 and wbDWI for side-by-side analysis without and with fused images were 72% and 89%, and 74% and 91%, respectively. The detection rate was significantly higher with side-by-side analysis and fused image analysis compared with wbT2 and wbDWI alone (p = .0159; p < .0001). There was no significant difference between fused image interpretation and side-by-side analysis.<bold>Conclusions: </bold>WbDWI allows detection of malignant lesions with a similar detection rate to wbT2. Side-by-side analysis of wbT2 and wbDWI significantly improves the overall detection rate and fused image data provides no added value.
- Publication
European Radiology, 2011, Vol 21, Issue 2, p246
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1929-x