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- Title
PET and SPECT studies in children with hemispheric low-grade gliomas.
- Authors
Juhász, Csaba; Bosnyák, Edit
- Abstract
Molecular imaging is playing an increasing role in the pretreatment evaluation of low-grade gliomas. While glucose positron emission tomography (PET) can be helpful to differentiate low-grade from high-grade tumors, PET imaging with amino acid radiotracers has several advantages, such as better differentiation between tumors and non-tumorous lesions, optimized biopsy targeting, and improved detection of tumor recurrence. This review provides a brief overview of single-photon emission computed tomography (SPECT) studies followed by a more detailed review of the clinical applications of glucose and amino acid PET imaging in low-grade hemispheric gliomas. We discuss key differences in the performance of the most commonly utilized PET radiotracers and highlight the advantage of PET/MRI fusion to obtain optimal information about tumor extent, heterogeneity, and metabolism. Recent data also suggest that simultaneous acquisition of PET/MR images and the combination of advanced MRI techniques with quantitative PET can further improve the pretreatment and post-treatment evaluation of pediatric brain tumors.
- Subjects
GLIOMAS; POSITRON emission tomography; SINGLE-photon emission computed tomography; RADIOACTIVE tracers; TUMORS in children; DIAGNOSIS
- Publication
Child's Nervous System, 2016, Vol 32, Issue 10, p1823
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-016-3125-z