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- Title
De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation.
- Authors
Bilginer, Burcak; Türk, Cezmi; Narin, Fırat; Hazer, Burcu; Hanalioglu, Sahin; Oguz, Kader; Soylemezoglu, Figen; Akalan, Nejat
- Abstract
Purpose: Tumors of central nervous system (CNS) are accounted as the second most common tumors in childhood (21 % of all cancers) following hematologic malignancies. The patients can suffer more than one cancer in their lifetime, and radiotherapy is claimed for de novo formation of a new tumor in years after treatment of an initial tumor. Methods: We have retrospectively analyzed our database for defining radiotherapy-related de novo brain tumors operated in between January, 2000 and August, 2012. New tumors in the field of radiotherapy were included into the study. Results: The retrospective analysis revealed six patients (two girls and four boys) eligible for further evaluation. The children were irradiated at an age in the range of 5 and 12 years (mean, 7.8). The primary diagnoses were hematological malignancies in two (acute lymphocytic leukemia and non-Hodgkin lymphoma (NHL)) and solid tumors in other four (two pilocytic astrocytoma, one craniopharyngioma, and one grade 3 astrocytoma). All patients received cranial radiotherapy. The mean latency period for the 'second tumor' was 9.5 years. The pathological diagnoses for de novo new tumors were as follows: glial tumor (two cases), medulloblastoma (two cases), mesenchymal tumor (one case), and meningeal sarcoma (one case). All de novo tumors were high graded. Mean survival was 14.6 months. Conclusions: de novo brain tumors after irradiation has poor prognosis in neurosurgical practice. Vigilance and awareness for possibility of de novo new tumor are warranted for both families and physicians at follow-ups even years after the treatment of initial tumors.
- Subjects
CENTRAL nervous system tumors; RADIOTHERAPY; BRAIN tumor treatment; HODGKIN'S disease; LYMPHOBLASTIC leukemia; CRANIOPHARYNGIOMA; ASTROCYTOMAS
- Publication
Child's Nervous System, 2015, Vol 31, Issue 6, p893
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-015-2689-3