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- Title
Prevention of Early Menopause Study (POEMS): is it possible to preserve ovarian function by gonadotropin releasing hormone analogs (GnRHa)?
- Authors
Gerber, B.; Ortmann, O.
- Abstract
Introduction: The effect of GnRHa in the preservation of ovarian function during a modern chemotherapy is still under discussion. Material and Method: In this News and Views article, we discuss the benefits and weaknesses of the recently presented POEMS. Results: The POEM study demonstrated an increased resumption of ovarian function and pregnancy rate after using GnRHa. GnRHa in HR-negative patients led to a significant increase in disease free and overall survival, with those effects being inexplicable. Weaknesses of the trial were prematurely close due to lack of recruitment, a drop-out rate of 38 % during follow-up and definition of hormone receptor negativity by <10 % positive stained cells. Conclusion: Even after POEMS, there is no additional clarity regarding preservation of ovarian function during chemotherapy by GnRHa.
- Subjects
PREMATURE menopause; DRUG therapy; PREMATURE ovarian failure; OVARIAN diseases; HEALTH outcome assessment; GONADOTROPIN releasing hormone; CHEMICAL derivatives
- Publication
Archives of Gynecology & Obstetrics, 2014, Vol 290, Issue 6, p1051
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-014-3493-0