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- Title
CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance.
- Authors
Horn, L.-C; Raptis, G.; Fischer, U.; Hentschel, B.; Köhler, U.; Richter, C.; Martin, R.
- Abstract
Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls ( P=0.04). There was no correlation to tumor stage ( P=0.61), lymphovascular space involvement ( P=0.075) or pelvic lymph node involvement ( P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.
- Subjects
CELL adhesion; MOLECULES; METASTASIS; TISSUES; TUMORS; LYMPH nodes
- Publication
Archives of Gynecology & Obstetrics, 2005, Vol 273, Issue 2, p104
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-005-0039-5