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- Title
E-Cadherin Gene 3′-UTR C/T Polymorphism Is Associated with Prostate Cancer.
- Authors
Hsi-Chin Wu; Ming-Tsung Lai; Chao-I Wu; Huey-Yi Chen; Lei Wan; Fuu-Jen Tsai; Wen-Chi Chen
- Abstract
Introduction: E-cadherin (CDH-1) is a cell-cell adhesive molecule which maintains cell integrity and communication between the intracellular and extracellular world. CDH-1 may therefore be related to carcinogenesis. A polymorphism located at the 3′-UTR of the CDH-1 gene is associated with stone disease; however, its relationship to prostate cancer has not been reported. We aimed to study whether there is an association between the 3′-UTR polymorphism and prostate cancer. Materials and Methods: We collected 96 patients with prostate cancer and 114 normal controls for this study. The polymorphism of the CDH-1 gene was studied by polymerase chain reaction-based restriction analysis. Results:There was a significant difference in genotype distribution of the CDH-1 gene polymorphism between cancer patients and normal controls (p < 0.001). The distribution of the CDH-1 gene CC genotype in prostate cancer patients (51.0%) was higher than in the controls (10.5%). The odds ratio for the CDH-1 ‘C’ allele was 2.896 (95% CI = 1.908–4.396). There was no significant difference according to age, pathological grading, clinical staging, and responsiveness to hormonal therapy among patients. Only 3 patients (3.1%) had a history of urolithiasis. Conclusions:The CDH-1 gene 3′-UTR C/T polymorphism is associated with prostate cancer. The ‘CC’ homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes. Copyright © 2005 S. Karger AG, Basel
- Subjects
CANCER patients; GENETIC polymorphisms; PROSTATE cancer; EXOCRINE glands; MALE reproductive organs; GENETIC toxicology; DNA polymerases; POLYMERASE chain reaction
- Publication
Urologia Internationalis, 2005, Vol 75, Issue 4, p350
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000089173