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- Title
4-Hydroxy-2-quinolones 166*. Synthesis, isomerism, and antitubercular activity of 3-arylaminomethylene-quinoline-2,4-(1H,3H)-diones.
- Authors
Ukrainets, I. V.; Liu Yangyang; Tkach, A. A.; Turov, A. V.
- Abstract
Condensation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbaldehydes, thioglycolic acid (or methyl thioglycolate), and anilines does not lead to the synthesis of the corresponding thiazolidinylquinolones because the Schiff bases so formed exist exclusively in a form inert to enamine thioglycolates. 1H NMR spectroscopy showed that the main components of the isolated 3-arylaminomethylenequinoline-2,4-(1H,3H)-diones are E-isomers. The results of a study of the antitubercular properties of the compounds obtained are presented.
- Subjects
MOLECULAR rotation; HYDROXY acids; AROMATIC amines; QUINOLONE antibacterial agents; QUINOLINE; SCHIFF bases
- Publication
Chemistry of Heterocyclic Compounds, 2009, Vol 45, Issue 7, p802
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-009-0356-x