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- Title
Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models.
- Authors
A.Walters, K.; Simanainen, U.; Handelsman, D. J.
- Abstract
BACKGROUND: Androgens and the androgen receptor (AR) have well known roles in male reproduction, and recent genetic mouse models inactivating the Ar gene have conclusively defined a role for androgens in female reproduction. In males, AR gene inactivation severely disrupts spermatogenesis by interrupting completion of meiosis, thereby eliminating production of mature sperm leading to male sterility. These effects have overshadowed the study of additional post-meiotic androgen effects required for the production of fully functional spermatozoa, as well as the production of females with complete androgen insensitivity which cannot be produced by natural breeding. However, these limitations have been overcome by the creation of global and cell-specific AR knockout (ARKO) mouse models using Cre–LoxP genetic engineering.
- Subjects
ANDROGENS; MALE reproductive organs; GENETIC models; GENES; FEMALE reproductive organs; GENE silencing; SPERMATOGENESIS; MALE infertility
- Publication
Human Reproduction Update, 2010, Vol 16, Issue 5, p543
- ISSN
1355-4786
- Publication type
Article
- DOI
10.1093/humupd/dmq003