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- Title
Comparing the Effects of Lidocaine/Paracetamol and Midazolam/Fentanyl as a Premedication on Pain Intensity and Hemodynamic Changes in Patients Undergoing Cataract Surgery With Topical Anesthesia: A Randomized Double-blinded Pilot Study.
- Authors
Zarrin, Nasim; Khezri, Marzieh Beigom; Safaei, Raheleh; Oladi, Mohammad Reza
- Abstract
Background: Several supplementary approaches have been used to increase the patient's comfort during phacoemulsification under topical anesthesia. Objective: This study aimed to compare the effects of lidocaine/paracetamol (LP) and midazolam/fentanyl (MF) administration on pain intensity and hemodynamic changes in patients undergoing cataract surgery using phacoemulsification. Methods: This study was designed and implemented as a pilot randomized double-blinded clinical trial. A total number of 80 patients with cataracts scheduled for phacoemulsification were randomly assigned to two groups (40 subjects in each group) to receive lidocaine at a dose of 1.5 mg/kg and then infused with 1 g of paracetamol in 100 cc of normal saline (LP group) or midazolam 0.2 mg/kg and fentanyl 1.5 µg/kg (MF group). Hemodynamic parameters and sedation scores were measured before, 5, and 15 minutes after surgery, and then during recovery. Furthermore, pain (VAS), patient-surgeon satisfaction, propofol, and opioid consumption were all assessed. Findings: The sedation scores during recovery in the LP group were significantly lower (P= 0.04) than those in the MF group. Respiratory depression was also significantly lower (P<0.001) in the LP group compared to that infused by MF. According to other findings, no significant difference was observed between both study groups. Conclusion: The use of lidocaine-paracetamol as a supplementary approach for patients undergoing cataract surgery under topical anesthesia can cause better sedation scores with lower respiratory depression compared to the use of midazolam-fentanyl.
- Subjects
IRAN; LIDOCAINE; DRUG efficacy; PILOT projects; PHACOEMULSIFICATION; COMBINATION drug therapy; PAIN measurement; ANESTHESIA; ACETAMINOPHEN; FENTANYL; VISUAL analog scale; MANN Whitney U Test; FISHER exact test; PATIENT satisfaction; CATARACT surgery; RANDOMIZED controlled trials; T-test (Statistics); BLIND experiment; DESCRIPTIVE statistics; CHI-squared test; REPEATED measures design; MIDAZOLAM; HEMODYNAMICS; STATISTICAL sampling; DATA analysis software; LOCAL anesthetics; POSTOPERATIVE pain; THERAPEUTICS; EVALUATION
- Publication
Journal of Inflammatory Diseases, 2022, Vol 26, Issue 2, p79
- ISSN
2717-4158
- Publication type
Article
- DOI
10.32598/JID.26.2.5