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- Title
Chlorine and sodium chemical shift imaging during acute stroke in a rat model at 9.4 Tesla.
- Authors
Baier, Sebastian; Krämer, Philipp; Grudzenski, Saskia; Fatar, Marc; Kirsch, Stefan; Schad, Lothar
- Abstract
Object: A triple-resonant coil setup with an H linear resonator and a double-tuned Na/Cl surface coil was used to study the evolution of T and M for Cl and Na in a rat stroke model during the acute phase at 9.4 Tesla. Materials and methods: In vivo measurements were performed 1.5-7 h after onset of stroke ( n = 2), ten days after onset ( n = 1) and on a healthy control rat by a chemical shift imaging sequence. Measurement times were 15 min (Na) and 57 min (Cl). Results: The relaxation times ten days after onset [ T = 14.3 ± 1.8 ms (Na) and 6.0 ± 1.3 ms (Cl)] are clearly prolonged in comparison to a healthy rat [ T = 4.8 ± 0.6 ms (Na) and 2.1 ± 0.3 ms (Cl)] and the acute phase [ T = 5.6 ± 0.2 ms (Na) and 1.9 ± 0.1 ms (Cl)]. Conclusion: M in the infarcted region clearly rises later and slower for chlorine than for sodium. To the best of our knowledge, these are the first combined proton, sodium, and chlorine measurements in an animal stroke model during the acute phase.
- Subjects
BRAIN imaging; PHYSIOLOGICAL effects of chlorine; PHYSIOLOGICAL effects of sodium; LABORATORY rats; CHEMICAL shift (Nuclear magnetic resonance); STROKE diagnosis
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2014, Vol 27, Issue 1, p71
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-013-0398-z