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- Title
Immunobiology of the TAM receptors.
- Authors
Lemke, Greg; Rothlin, Carla V.
- Abstract
Recent studies have revealed that the TAM receptor protein tyrosine kinases--TYRO3, AXL and MER--have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.
- Subjects
PROTEIN-tyrosine kinases; DENDRITIC cells; KILLER cells; CELLULAR immunity; ENDOCYTOSIS; MEDICAL research; ANIMAL experimentation; CELL differentiation; CELL receptors; CELLULAR signal transduction; COMPARATIVE studies; IMMUNITY; INFLAMMATION; MACROPHAGES; RESEARCH methodology; MEDICAL cooperation; PHAGOCYTOSIS; PROTEINS; RESEARCH; TRANSFERASES; EVALUATION research
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 5, p327
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2303