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- Title
MOLECULAR EVALUATION OF CELL CYCLE INHIBITORS AFTER Hepatocellular carcinoma (HCC) TREATMENT In Vitro.
- Authors
NASR M. Y.; DARWISH, MONA M.; ELSABRUTI, A. F.; ROSHDY, WA. H.; EL-RABEAY, H. A.
- Abstract
Hepatocellular carcinoma (HCC) is one of the most prevalent types of cancer. HCC is the sixth most popular cancer in the world and the fourth most common cancer in Egypt, respectively. Egypt is the third and fifteenth most populated countries in Africa and the globe, respectively. The goal of this study is to examine the effect of graphene quantum dots (GQDs) on the expression of P21 & c-MYC genes on a cell line in liver cancer namely "HuH-7 cell line." The area of studying the anticancer effect of GQDs is attracting growing attention because of its valuable properties. Especially due to its nanosized sheets, it tends to infiltrate the cell nucleus and interfere with DNA function due to its ultra-small size. The results emphasize the validity of using GQDs as anticancer agent, with varied concentrations of GQDs inhibiting the development of cancer cells (HuH-7) via gene up regulation.
- Subjects
EGYPT; HEPATOCELLULAR carcinoma; CELL cycle; LIVER cancer; P21 gene; QUANTUM dots
- Publication
Egyptian Journal of Genetics & Cytology, 2022, Vol 51, Issue 1, p33
- ISSN
0046-161X
- Publication type
Article