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- Title
Study on the soothing and oil control efficacy of p-Hydroxyacetenoneophenone.
- Authors
GUO Shen-tao; XU Wen-feng; NIU Qiang; ZHANG Yu-ling; LONG Yan; PENG Chun-mei
- Abstract
p-Hydroxyacetophenone (p-HAP) has been used as a preservative in cosmetics, however, its new efficacy has rarely been reported. Herein, the soothing and oil control efficacy of p-HAP was evaluated by cellular in vitro method to provide new efficacy basis for application in cosmetics. The content of nitric oxide (NO), tumor necrosis factor a (TNF-α) and interleukin-6 (IL-6) was determined in LPS-induced RAW264.7. The lipid content was determined in testosterone-induced SZ95. The results revealed that p-HAP could significantly inhibit these pro-inflammatory cytokines, including NO, TNF-α and IL-6 (P < 0.01). In addition, 0.05 mg/mLp-HAP could inhibit the formation of lipid droplets in human sebocytes, with inhibition rate of 17.64% (P < 0.001). These findings might imply the potential application of p-HAP as a functional ingredient in cosmetics, which might have soothing and oil control efficacy according to the inhibition of pro-inflammatory cytokines and lipid content.
- Publication
Detergent & Cosmetics, 2023, Vol 46, Issue 10, p14
- ISSN
1006-7264
- Publication type
Article
- DOI
10.3969/j.issn.1006-7264.2023.10.004