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- Title
Associations of Brain Structure With Adiposity and Changes in Adiposity in a Middle-Aged and Older Biracial Population.
- Authors
Windham, B. Gwen; Lirette, Seth T.; Fornage, Myriam; Benjamin, Emelia J.; Parker, Kirby G.; Turner, Stephen T.; Jack Jr., Clifford R.; Griswold, Michael E.; Mosley, Thomas H.; Jack, Clifford R Jr
- Abstract
<bold>Background: </bold>Studies of adiposity and brain pathology in African Americans (AA) are sparse despite higher rates of obesity, dementia, and dementia-associated brain pathology in AA. This study examined relations of adiposity to white matter hyperintensities (WMH) and total brain volume (TBV) in AA and non-Hispanic whites (NHW).<bold>Methods: </bold>Waist circumference (WC) and body mass index (BMI) were measured in the Genetic Epidemiology Network of Arteriopathy study at Visits 1 (mean age 57 [±11]) and 2 (mean age 61 [±10], mean 5.2 years later). Brain MRIs were obtained shortly after Visit 2 in 1,702 participants (64% women, 48% AA). Multilevel linear regression using generalized estimating equation estimated associations of adiposity (cross-sectional) or adiposity changes with WMH (accounting for intracranial size) or TBV adjusting for demographics, cardiovascular risk factors, and incorporating adiposity-by-race interactions. Adiposity-by-age interactions were examined.<bold>Results: </bold>Concurrent TBV was inversely associated with BMI (β = -2.76 [95% confidence interval (CI): -4.99, -0.53]) and WC (β = -2.19 [CI: -4.04, -0.34]). Concurrent WMH were negatively associated with BMI (β = -0.04 [CI: -0.06, -0.01]) and, among NHW, with WC (β = -0.04 [CI: -0.06, -0.02]) but not with changes in BMI or WC. BMI increases were associated with lower TBV (β = -16.20, [CI: -30.34, -2.06]) in AA but not in NHW (β = -2.76 [CI: -14.02, 8.51]), although race-by-adiposity interactions were not supported. WC increases were not associated with MRI outcomes.<bold>Conclusion: </bold>Greater measures of obesity and increases in measures of obesity, which are common in mid-life, could be detrimental to brain health, particularly in AA.
- Subjects
MINNESOTA; MISSISSIPPI; WAIST circumference; MAGNETIC resonance imaging; OBESITY; OBESITY risk factors; OBESITY treatment; MULTIRACIALITY; REGRESSION analysis; DIAGNOSIS; HYPERTENSION epidemiology; AGING; BLACK people; BRAIN; WHITE people; BODY mass index
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2017, Vol 72, Issue 6, p825
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glw239