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- Title
Moderne Methoden zur Proteindifferenzierung im Urin.
- Authors
Hofmann, W.; Guder, W. G.
- Abstract
The usual laboratory diagnostic program for detection of renal diseases does not fulfill all medical requirements. A modern strategy should be able to quantify and differentiate proteinuria. This means, that glomerular, tubular änd extrarenal forms should be differentiated. This is realized by quantification of marker proteins (IgG, albumin, α1-microglobulin, N-acetyl-ß-D-glucosaminidase) in combination with total protein. Relating the concentrations measured in the second morning urine to g creatinine (mmol creatinine) can reduce different biological influence factors (diuresis, diurnal rhythm) and errors in sample collection. A renal dysfunction can be excluded with high probability if normal values for the excretion rates of marker proteins, leucocyte esterase and hemoglobin peroxidase (dipstick results) are obtained. Positive results are differentiated by a diagnostic strategy which includes besides quantitative measurements of proteins morphological (phase contrast microscopy, cytology), immunological (immunofixation) and electrophoretic procedures.
- Publication
Journal of Laboratory Medicine / Laboratoriums Medizin, 1989, Vol 13, Issue 9, p336
- ISSN
0342-3026
- Publication type
Article