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- Title
四种不同化疗方案在侵蚀性葡萄胎患者中的疗效比较及药物经济学评价.
- Authors
张哲; 文婷; 梁宏岩; 徐素梅; 吕淑河
- Abstract
Objective: To comparative clinical curative effects and pharmacoeconomics evaluation of four different chemotherapy regimens with invasive mole. Methods: Retrospective analysis were used to analyzed 76 cases of invasive mole patients enrolled from January 2014 to January 2017 in hospital. Patients were divided into four groups: methotrexate, actinomycin, EMA-CO, 5-Fu+ actinomycin. The clinical curative effects, pharmacoeconomics evaluation and side effect of the four groups were analyzed. Results: There were no difference in age, treatment expenses and clinical curative effects of the four groups. The MTX group had lowest medicine expenses (5876.5 ± 644.9 yuan, P<0.01), cost-effectiveness ratio (286.74 yuan) and highest side effect (myelosuppression). The incremental cost-effectiveness ratios were all more than 2000 yuan in the other three groups compared with MTX group. EMA-CO group had lower medicine expenses compared with 5-Fu+actinomycin group (36027.2± 1792.2 yuan vs 60215.2± 3632.8 yuan, P<0.01) in combined chemotherapy regimens, and the EMA-CO group also had obvious advantage on incremental cost-effectiveness ratio(2542.69 yuan vs 7963.19 yuan). Conclusions: For invasive mole patients, different chemotherapy regimens had similar clinical curative effects. MTX group had lowest medicine cost, while the other three groups had lower incremental cost-effectiveness ratio. The other three groups also still had advantages considering lower incidence rates of side effect and hospital day.
- Subjects
CHEMOTHERAPY complications; MOLAR pregnancy; METHOTREXATE; ACTINOMYCIN; CURATIVE medicine; DIAGNOSIS; THERAPEUTICS
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 8, p1569
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.08.036