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- Title
Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity.
- Authors
Bogdanov, A. V.; Voloshina, A. D.; Strobykina, A. S.; Kulik, N. V.; Mironov, V. F.; Zaripova, I. F.; Bukharov, S. V.
- Abstract
Condensation reactions of isatin derivatives with 3,5-di(tert-butyl)-4-hydroxybenzyl acetate and the Girard's reagent T has afforded a series of novel water-soluble isatin-3-acyl hydrazones containing a sterically hindered phenolic fragment in position 1 of the heterocycle; antimicrobial activity of the products has been estimated. It has been shown that the isatin derivatives with bromine or methoxy substituent in the benzo fragment as well as the acyl hydrazones containing 5-methyl or 5-ethyl group are the most active against Staphylococcus aureus and Bacillus cereus.
- Subjects
ISATIN; HYDRAZONES; ANTI-infective agents; BACILLUS cereus; STAPHYLOCOCCUS aureus
- Publication
Russian Journal of General Chemistry, 2018, Vol 88, Issue 1, p57
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363218010097