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- Title
Remarkable response of a patient with secondary glioblastoma to a histone deacetylase inhibitor.
- Authors
Gurbani, Saumya S; Weinberg, Brent D; Salgado, Eric; Voloschin, Alfredo; Vega, Jose Enrique Velazquez; Olson, Jeffrey J; Shu, Hui-Kuo G; Shim, Hyunsuk
- Abstract
Secondary glioblastoma is a rare brain tumor characterized by a mutation in isocitrate dehydrogenase, which is reported to lead to epigenetic modification. Patients with secondary glioblastoma experience poor survival and quality-of-life outcomes due to the disease's aggressiveness and a lack of targeted therapies. In this report, a patient with a secondary glioblastoma was treated with a histone deacetylase inhibitor, an epigenetic drug with potent anti-inflammatory properties, in addition to the standard regimen. The patient showed very favorable survival and quality-of-life measures, and a restoration of several neuro-metabolites as measured by spectroscopic magnetic resonance imaging.
- Subjects
HISTONE deacetylase inhibitors; GLIOBLASTOMA multiforme; OLIGODENDROGLIOMAS; ISOCITRATE dehydrogenase; BRAIN tumors; MAGNETIC resonance imaging; HISTONE deacetylase
- Publication
Oxford Medical Case Reports, 2020, Vol 20, Issue 3, p1
- ISSN
2053-8855
- Publication type
Article
- DOI
10.1093/omcr/omaa006