We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
DNA methylation is not involved in dietary restriction induced lifespan extension in adult Drosophila.
- Authors
TING LIAN; GAUR, UMA; QI WU; JIANBO TU; BOYUAN SUN; DEYING YANG; XIAOLAN FAN; XUEPING MAO; MINGYAO YANG
- Abstract
Dietary restriction (DR) is widely regarded as a viable intervention to extend lifespan and healthspan in diverse organisms. The precise molecular regulatory mechanisms are largely unknown. Epigenetic modifications are not stable upon DR and also keep changing with age. Here, we employed whole genome bisulfite sequencing to determine the DNA methylation changes upon DR in adult Drosophila. Our results indicate that although a low level of DNA methylation exists in the adult Drosophila genome, there is no significant difference in DNA methylation levels upon DR when compared to unrestricted flies. This suggests that other epigenetic components such as histone modifications might be altered by DR.
- Subjects
DNA methylation; METHYLATION; DROSOPHILA; WHOLE genome sequencing; ADULTS
- Publication
Genetics Research, 2018, Vol 100, p1
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672317000064