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- Title
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation.
- Authors
Nagashima, Toshiko; Sato, Fumie; Chuma, Takayo; Mano, Yukio; Sasaki, Isao; Mori, Masamitsu; Higa, Toshio; Masauji, Nobuo; Kasai, Masaharu; Orba, Yasuko; Shinohara, Toshiya; Nagashima, Kazuo
- Abstract
In recent years a novel problem has arisen in organ transplantation medicine, namely GVHD. The nervous system has been involved mainly at the level of the CNS and this can lead to a serious outcome for the patient. In rare cases, peripheral nerves may be affected and show acute or chronic polyneuropathy. Here a case is reported of polyneuropathy associated with chronic GVHD. A 32-year-old man, suffering from chronic GVHD following an allogeneic bone marrow transplantation (BMT) for malignant lymphoma at the age of 25, developed a motor dominant polyneuropathy 5 years later. Electrophysiologic studies demonstrated the demyelinating type of polyneuropathy. Biopsy specimens from skin and skeletal muscle disclosed perivascular lymphocytic infiltrates expressing T-cell markers. The sural nerve showed a loss of myelinated nerve fibers with epineurial fibrosis and rare occurrence of T cells, but without obvious vasculitic changes. The present case suggested that polyneuropathy could develop in association with chronic GVHD in some patients with a longstanding disease course.
- Subjects
POLYNEUROPATHIES; GRAFT versus host disease; BONE marrow transplant complications
- Publication
Neuropathology, 2002, Vol 22, Issue 1, p1
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1046/j.0919-6544.2002.00419.x