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- Title
The mitochondrial secret(ase) of Alzheimer's disease.
- Authors
Young KJ; Bennett JP; Young, Kisha J; Bennett, James P
- Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by progressive decline in memory and cognition and pathologically by extracellular amyloid-beta (Abeta) deposits and intraneuronal aggregates of hyperphosphorylated tau. Since its proposal in 1992, the amyloid cascade hypothesis implicates Abeta overproduction as a causative event in disease pathogenesis, and this thinking has predominated the field's understanding of AD pathogenesis and the development of potential therapeutics (i.e., Abeta-reducing agents). Though Abeta has been shown to induce AD pathology, unanswered questions for sporadic AD development suggests this hypothesis is best applied to familial disease only. The more recent mitochondrial cascade hypothesis is supported by data showing that early impairments of mitochondrial dysfunction and oxidative stress may precede Abeta overproduction and deposition. However, the development of Abeta-reducing agents continues. Unfortunately, these agents have not been efficiently tested for their effect on one of the earliest AD pathologies, i.e., mitochondrial dysfunction. This paper will review supporting data for the amyloid and mitochondrial cascade hypotheses, reports of the effects of secretase inhibitors on AD-phenotypic cells and animals, and begin to look at a potential role for gamma-secretase, which is localized to mitochondria, in AD-related mitochondrial dysfunction.
- Publication
Journal of Alzheimer's Disease, 2010, Vol 20, Issue 2, p381
- ISSN
1387-2877
- Publication type
journal article
- DOI
10.3233/JAD-2010-100360