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- Title
Mixed lanthanide oxide nanoparticles as dual imaging agent in biomedicine.
- Authors
Wenlong Xu; Badrul Alam Bony; Cho Rong Kim; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Tae Jeong Kim; Gang Ho Lee
- Abstract
There is no doubt that the molecular imaging is an extremely important technique in diagnosing diseases. Dual imaging is emerging as a step forward in molecular imaging technique because it can provide us with more information useful for diagnosing diseases than single imaging. Therefore, diverse dual imaging modalities should be developed. Molecular imaging generally relies on imaging agents. Mixed lanthanide oxide nanoparticles could be valuable materials for dual magnetic resonance imaging (MRI)-fluorescent imaging (FI) because they have both excellent and diverse magnetic and fluorescent properties useful for dual MRI-FI, depending on lanthanide ions used. Since they are mixed nanoparticles, they are compact, robust, and stable, which is extremely useful for biomedical applications. They can be also easily synthesized with facile composition control. In this study, we explored three systems of ultrasmall mixed lanthanide (Dy/Eu, Ho/Eu, and Ho/Tb) oxide nanoparticles to demonstrate their usefulness as dual T2 MRI-FI agents.
- Subjects
NANOPARTICLES; RARE earth oxides; MEDICINE; MAGNETIC resonance imaging; MEDICAL imaging systems
- Publication
Scientific Reports, 2013, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep03210