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- Title
CD38: T Cell Immuno-Metabolic Modulator.
- Authors
Kar, Anwesha; Mehrotra, Shikhar; Chatterjee, Shilpak
- Abstract
Activation and subsequent differentiation of T cells following antigenic stimulation are triggered by highly coordinated signaling events that lead to instilling cells with a discrete metabolic and transcriptional feature. Compelling studies indicate that intracellular nicotinamide adenine dinucleotide (NAD+) levels have profound influence on diverse signaling and metabolic pathways of T cells, and hence dictate their functional fate. CD38, a major mammalian NAD+ glycohydrolase (NADase), expresses on T cells following activation and appears to be an essential modulator of intracellular NAD+ levels. The enzymatic activity of CD38 in the process of generating the second messenger cADPR utilizes intracellular NAD+, and thus limits its availability to different NAD+ consuming enzymes (PARP, ART, and sirtuins) inside the cells. The present review discusses how the CD38-NAD+ axis affects T cell activation and differentiation through interfering with their signaling and metabolic processes. We also describe the pivotal role of the CD38-NAD+ axis in influencing the chromatin remodeling and rewiring T cell response. Overall, this review emphasizes the crucial contribution of the CD38−NAD+ axis in altering T cell response in various pathophysiological conditions.
- Subjects
T cells; T cell differentiation; CELL differentiation; POLY(ADP-ribose) polymerase
- Publication
Cells (2073-4409), 2020, Vol 9, Issue 7, p1716
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells9071716