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- Title
Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.
- Authors
Park, Hyun-Joo; Kim, Yeon; Kim, Mi-Kyoung; Hwang, Jae Joon; Kim, Hyung Joon; Bae, Soo-Kyung; Bae, Moon-Kyoung
- Abstract
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs). This attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in VSMCs. Moreover, the treatment with RC-3095 effectively ameliorated phosphate-induced calcium deposition in rat aortas ex vivo and aortas of chronic kidney disease in mice in vivo. Therefore, the regulation of the GRP-GRP receptor axis may be a potential strategy for treatment of diseases associated with excessive vascular calcification.
- Subjects
VASCULAR smooth muscle; CALCIFICATION; PHOSPHATES; BLOOD vessels; GENE silencing; CHRONIC kidney failure
- Publication
Cells (2073-4409), 2020, Vol 9, Issue 3, p737
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells9030737