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- Title
Pancreatic polypeptide: A potential biomarker of glucose‐dependent insulinotropic polypeptide receptor activation in vivo.
- Authors
Veedfald, Simon; Bergmann, Natasha C.; Vilsbøll, Tina; Christensen, Mikkel B.; Holst, Jens J.; Knop, Filip K.
- Abstract
The article presents a insulinotropic gut hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), are key factors in the regulation of normal postprandial glucose homeostasis, but the glucose-lowering effect of GIP has been shown to be blunted with type 2 diabetes. Topics include the GIP does not potentiate the glucose-lowering effect of GLP-1 in type 2 diabetes, and the biomarker of GIP receptor activation measurable in plasma and/or serum is needed.
- Subjects
BIOMARKERS; TYPE 2 diabetes; GLUCAGON-like peptides; PANCREATIC hormones; PEPTIDES
- Publication
Diabetic Medicine, 2021, Vol 38, Issue 8, p1
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.14592