We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B.
- Authors
Kato, T.; Itoh, M.; Hanashita, J.; Itoi, T.; Matsumoto, T.; Ono, Y.; Imamura, S.; Hayakawa, N.; Suzuki, A.; Mizutani, Y.; Uchigata, Y.; Oda, N.
- Abstract
Aims A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.
- Subjects
HYPOGLYCEMIA; AUTOIMMUNE diseases; IMMUNOGLOBULINS; INSULIN receptors; LYMPHOCYTES; STEROIDS
- Publication
Diabetic Medicine, 2007, Vol 24, Issue 11, p1279
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2007.02232.x