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- Title
Prostate cancer incidence on cystoprostatectomy specimens is directly linked to age: results from a multicentre study.
- Authors
Pignot, Géraldine; Salomon, Laurent; Lebacle, Cédric; Neuzillet, Yann; Lunardi, Pierre; Rischmann, Pascal; Zerbib, Marc; Champy, Cecile; Roupret, Morgan; Peyronnet, Benoit; Verhoest, Gregory; Murez, Thibault; Quintens, Herve; Larré, Stéphane; Houédé, Nadine; Compérat, Eva; Soulié, Michel; Pfister, Christian
- Abstract
Objective To assess the incidence and age-related histopathological characteristics of incidentally diagnosed prostate cancer from specimens obtained via radical cystoprostatectomy ( RCP) for muscle-invasive bladder cancer. Patients and Methods A retrospective review of the histopathological features of 2424 male patients who underwent a RCP for bladder cancer was done at eight centres between January 1996 and June 2012. No patient had preoperative suspicion of prostate cancer. Statistical analyses were performed in different age-related groups. Results Overall, prostate cancer was diagnosed in 518 men (21.4%). Incidences varied significantly according to age (5.2% in those aged <50 years to 30.5% in those aged >75 years, P < 0.001). Most of the prostate cancers were considered as 'non-aggressive', that is to say organ-confined (≤ pT2) and well-differentiated (Gleason score <7). Tumour-Node-Metastasis ( TNM) stage and proportion with a Gleason score of ≥7 were significantly greater in older patients ( P < 0.001). Apart from age, there were no preoperative predictive factors for 'non-aggressive' prostate-cancer status. At the end of the follow-up, only nine patients (1.7%) had biochemical recurrence of prostate cancer, and no preoperative predictive factors were identified. Conclusion The rate of incidentally diagnosed prostate cancer from RCP specimens is ≈20%, most of them being organ-confined and well-differentiated. The probability of having a 'non-aggressive' prostate cancer decreases in older men.
- Subjects
PROSTATE cancer; DIAGNOSTIC specimens; BLADDER cancer; RETROSPECTIVE studies; METASTASIS; PROBABILITY theory
- Publication
BJU International, 2015, Vol 115, Issue 1, p87
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.12803