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- Title
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
- Authors
Go, Min Jin; Hwang, Joo-Yeon; Kim, Young Jin; Hee Oh, Ji; Kim, Yeon-Jung; Heon Kwak, Soo; Soo Park, Kyung; Lee, Juyoung; Kim, Bong-Jo; Han, Bok-Ghee; Cho, Myeong-Chan; Cho, Yoon Shin; Lee, Jong-Young
- Abstract
Most recently, 1-h hyperglycemia has been recognized as an additional risk factor for type 2 diabetes. To date, previous genome-wide association studies for glycemic traits have a limited impact on the fasting state and 2-h plasma glucose level in an oral glucose challenge. To identify genetic susceptibility in different stages of glucose tolerance, we performed a meta-analysis for glycemic traits including 1-h plasma glucose (1-hPG) from 14 232 non-diabetic individuals in the Korean population. Newly implicated variants (MYL2, C12orf51 and OAS1) were found to be significantly associated with 1-hPG. We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia.
- Subjects
TYPE 2 diabetes risk factors; DISEASE susceptibility; BLOOD sugar; GENETICS of type 2 diabetes; KOREANS; GLYCEMIC index; GESTATIONAL diabetes; CLINICAL medicine; DISEASES
- Publication
Journal of Human Genetics, 2013, Vol 58, Issue 6, p362
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2013.14