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- Title
Rethinking vaccination in multiple sclerosis: The way forward.
- Authors
Reyes, Saúl; Otero-Romero, Susana
- Abstract
The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. The treatment of multiple sclerosis (MS) has significantly changed over the past two decades with the introduction of new and more effective disease-modifying therapies (DMTs).[1] However, newer DMTs have known and potential safety issues, which have prompted clinicians to optimize infection mitigation strategies.[1] Among them, vaccination has become a fundamental marker of proactive care of patients with MS (pwMS).[2] Vaccination is undeniably responsible for improved health outcomes globally and, encouragingly, there is increasing awareness that vaccinations are designed to promote health and well-being not only in children but also in adults, especially those from vulnerable populations.[3] PwMS exposed to immunosuppressive therapies and/or those with high disability may be at increased risk of worse outcomes from some vaccine-preventable infections.[4] The use of DMTs that may influence the immune response against vaccines and/or their safety is also a matter of concern.[4] Literature from before the COVID-19 pandemic indicates that vaccines are safe and effective for the vast majority of pwMS.[4] This was further confirmed during COVID-19 vaccination efforts.[5] The best available evidence shows no disease-related influence on vaccination response and, reassuringly, no link between vaccination and the onset or exacerbation of MS.[4] Although some specific considerations should be kept in mind when planning vaccination strategies for pwMS, it is not a difficult task.
- Subjects
CHICKENPOX; JOHN Cunningham virus; MULTIPLE sclerosis; VACCINATION; NEUROMYELITIS optica; MEDICAL personnel
- Publication
Multiple Sclerosis Journal, 2023, Vol 29, Issue 11/12, p1351
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585231204126