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- Title
Real-World Evidence of Trastuzumab, Pertuzumab, and Docetaxel Combination as a First-Line Treatment for Korean Patients with HER2-Positive Metastatic Breast Cancer.
- Authors
Yong-Pyo Lee; Min-Sang Lee; HongSik Kim; Ji-Yeon Kim; Jin Seok Ahn; Young-Hyuck Im; Yeon Hee Park
- Abstract
Purpose Trastuzumab has markedly improved the survival outcomes of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, and dual blockade of HER2 using trastuzumab and pertuzumab in combination with taxanes (THP) has become a standard of care for HER2-positive metastatic breast cancer (MBC) worldwide since the CLEOPATRA trial. We assessed the outcomes of THP as a first-line treatment for Korean HER2-positive MBC patients in the real-world setting. Materials and Methods Between August 2008 and October 2020, we identified 228 HER2-positive MBC patients who received THP as a first-line palliative chemotherapy. We analyzed survival outcomes, efficacy, and adverse events of THP retrospectively. Results After a median follow-up duration of 28.7 months, median overall survival and progression-free survival were 58.3 months (95% confidence interval [CI], 36.6 to 80.0) and 19.1 months (95% CI, 16.2 to 21.9), respectively. Better survival outcomes were observed in patient who received docetaxel for more than six cycles. Patients exposed to anti-HER2 directed therapies in a perioperative setting had poor survival outcomes. The overall response rate was 86.8% with a complete response (CR) rate of 17.7%. Among responders, 16.7% of patients sustained THP over 35 months and showed better survivals and higher CR rates. Adverse events were comparable to those reported in previous studies. Conclusion In a real-world context, clinical outcomes of Korean HER2-positive MBC patients treated with THP were similar to those of patients in the CLEOPATRA trial. Much longer follow-up results would be warranted.
- Subjects
CLEOPATRA, Queen of Egypt, d. 30 B.C.; HER2 positive breast cancer; METASTATIC breast cancer; KOREANS; TRASTUZUMAB; EPIDERMAL growth factor receptors
- Publication
Cancer Research & Treatment, 2022, Vol 54, Issue 4, p1130
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2021.1103