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- Title
Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation.
- Authors
Kwak, Hee-Jin; Park, Myung-Jin; Park, Chang-Min; Moon, Sang-Ik; Yoo, Doo-Hyun; Lee, Hyung-Chahn; Lee, Seung-Hoon; Kim, Mi-Suk; Lee, Hyean-Woo; Shin, Woon-Seob; Park, In-Chul; Rhee, Chang Hun; Hong, Seok-Il
- Abstract
Emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component in the root and rhizome of Rheum palmatum, is a tyrosine kinase inhibitor with a number of biological activities, including antitumor effects. Here, we examine the effects of emodin on vascular endothelial growth factor (VEGF)-A-induced angiogenesis, both in vitro and in vivo. In vitro, emodin dose-dependently inhibits proliferation, migration into the denuded area, invasion through a layer of Matrigel and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated with VEGF-A. Emodin also inhibits basic fibroblast growth factor-induced proliferation and migration of HUVECs and VEGF-A-induced tube formation of human dermal microvascular endothelial cells. Specifically, emodin induces the cell cycle arrest of HUVECs in the G
- Publication
International Journal of Cancer, 2006, Vol 118, Issue 11, p2711
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.21641