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- Title
Total loss of MHC class I is an independent indicator of good prognosis in breast cancer.
- Authors
Madjd, Zahra; Spendlove, Ian; Pinder, Sarah E.; Ellis, Ian O.; Durrant, Lindy G.
- Abstract
Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patients with primary operable invasive breast cancer was evaluated for the expression of MHC Class I heavy and light by immunohistochemical staining of 439 breast carcinomas in a tissue microarray. Forty-seven percent (206 of 439) of breast carcinomas were considered negative for HLA Class I heavy chain (HC10), whereas lack of anti-β
- Publication
International Journal of Cancer, 2005, Vol 117, Issue 2, p248
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.21163