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- Title
Association of the 5-HT<sub>2A</sub> receptor gene promoter polymorphism-1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study.
- Authors
Kang, Qing; Chen, Jue; Yu, Shunying; Yuan, Aihua; Zhang, Yanxia; Zhang, Ran; Jiang, Wenhui; Zhang, Chen; Zhang, Haiyin; Zhang, Mingdao; Xiao, Zeping
- Abstract
Objective The aim of the study was to explore the possible role of the 5-HT2A-1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. Methods The -1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating-disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. Results Neither the case-control analysis nor the transmission disequilibrium test revealed significant associations between the -1438G/A polymorphism and AN ( P > .05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE-Q6.0 than those of GA heterozygotes ( P < .05). Discussion Our findings suggested that female AN patients with 5-HT2A −1438AA genotype may be characterized by less severe eating-disordered psychopathological traits in the Chinese Han population.
- Subjects
PROMOTERS (Genetics); GENETIC polymorphisms; ANOREXIA nervosa; PATHOLOGICAL psychology; EATING disorders
- Publication
Asia-Pacific Psychiatry, 2017, Vol 9, Issue 3, pn/a
- ISSN
1758-5864
- Publication type
Article
- DOI
10.1111/appy.12284