We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions.
- Authors
Calcaterra, Valeria; Cena, Hellas; De Giuseppe, Rachele; Biino, Ginevra; Grazi, Roberta; Manuelli, Matteo; Zanelli, Sara; Tagi, Veronica; Vincenti, Alessandra; Zuccotti, Gianvincenzo; Fabiano, Valentina
- Abstract
Background: The identification of vitamin D (VitD) deficiency in pediatric populations is essential for preventive healthcare. We refined and tested the Evaluation of Deficiency Questionnaire (EVIDENCe-Q) for its utility in detecting VitD insufficiency among children. Patients and methods: We enrolled 201 pediatric patients (aged between 3 and 18 years). Clinical evaluation and serum vitamin D levels were assessed in all subjects. The EVIDENCe-Q was updated to incorporate factors influencing VitD biosynthesis, intake, assimilation, and metabolism, with scores spanning from 0 (optimal) to 36 (poor). Results: We established scores for severe deficiency (<10 mg/dL) at 20, deficiency (<20 mg/dL) at 22, and insufficiency (<30 mg/dL) at 28. A score of 20 or greater was determined as the optimal cut-off for distinguishing VitD deficient from sufficient statuses, as evidenced by ROC curve analysis AUC = 0.7066; SE = 0.0841; sensitivity 100%, 95% CI 0.561–1. The most accurate alignment was seen with VitD insufficiency, defined as 25-OH-D3 < 20 ng/mL. Conclusions: This study confirms that the EVIDENCe-Q is a valid instrument for assessing the risk of vitamin D deficiency and insufficiency in children. It offers a practical approach for determining the need for clinical intervention and dietary supplementation of VitD in the pediatric population.
- Subjects
VITAMIN D deficiency; RISK assessment; RECEIVER operating characteristic curves; T-test (Statistics); RESEARCH funding; QUESTIONNAIRES; DESCRIPTIVE statistics; ANALYSIS of variance; MEDICAL screening; CONFIDENCE intervals; DATA analysis software; VITAMIN D; SENSITIVITY &; specificity (Statistics); EVALUATION; DISEASE risk factors; CHILDREN
- Publication
Nutrients, 2024, Vol 16, Issue 7, p971
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16070971