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- Title
In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices.
- Authors
Ruiz de Azua, Ma. Josefina; Cruz-Carrión, Álvaro; Muguerza, Begoña; Aragonès, Gerard; Arola-Arnal, Anna; Romero, María Paz; Bravo, Francisca Isabel; Suarez, Manuel
- Abstract
Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. The hepatic gene expression of key enzymes in lipid metabolism was also evaluated. Animals were classified in three photoperiods (L6, L12, and L18) and in three treatments (vehicle: VH; local tomato: LT; and non-local tomato: nLT). We measured serum metabolic parameters and the gene expression of liver enzymes related to lipid metabolism (Acc1, Cpt1a, Had, Fas1, Srebp-1c, Fatp5, Cd36). LT consumption in season decreased cardiovascular risk 1 and coefficient atherogenic by 1.81 (p = 0.031) and in L6 decreased TAG and glucose (p = 0.046; p = 0.024). The L18-LT animals had decreased total cholesterol (p = 0.029) and gene expression of Srebp1-c (p = 0.022) but increased expression of Acc1 (p = 0.032). The treatments significantly affected the expression of Acc1 and Fas1 in the liver and the levels of serum TAG and glucose. A significant effect of photoperiod on serum concentration of glucose, insulin, HOMA index, and on the hepatic expression of Srep1-c, Fas1, and Acc1 was observed.
- Subjects
CARDIOVASCULAR diseases risk factors; BIOLOGICAL models; ANIMAL experimentation; POPULATION geography; SEASONS; RATS; GENE expression; DESCRIPTIVE statistics; RESEARCH funding; TOMATOES
- Publication
Nutrients, 2023, Vol 15, Issue 1, p43
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15010043