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- Title
Precision Nutrition in NAFLD: Effects of a High-Fiber Intervention on the Serum Metabolome of NAFD Patients—A Pilot Study.
- Authors
Stachowska, Ewa; Maciejewska-Markiewicz, Dominika; Palma, Joanna; Mielko, Karolina Anna; Qasem, Badr; Kozłowska-Petriczko, Katarzyna; Ufnal, Marcin; Sokolowska, Katarzyna Ewa; Hawryłkowicz, Victoria; Załęska, Patrycja; Jakubczyk, Karolina; Wunsch, Ewa; Ryterska, Karina; Skonieczna-Żydecka, Karolina; Młynarz, Piotr
- Abstract
Non-alcoholic fatty liver disease (NAFLD) is associated with dysfunction of the intestinal microbiota and its metabolites. We aimed to assess whether replacing bread with high-fiber buns beneficially changes the metabolome in NAFLD patients. This study involved 27 adult patients with NAFLD validated by FibroScan® (CAP ≥ 234 dB/m). Patients were asked to replace their existing bread for two meals with high-fiber buns. In this way, the patients ate two rolls every day for 2 months. The following parameters were analysed (at the beginning and after 2 months): the anthropometric data (BIA), eating habits (24 h food recalls), gut barrier markers (lipopolysaccharide S and liposaccharide binding protein (LPS, LBP)), serum short-chain fatty acids (SCFAs) and branched chain fatty acids (BCFAs) by GC/MS chromatography, as well as serum metabolites (by 1H NMR spectroscopy). After 2 months of high-fiber roll consumption, the reduction of liver steatosis was observed (change Fibroscan CAP values from 309–277 dB/m). In serum propionate, acetate, isovaleric, and 2-methylbutyric decrease was observed. Proline, choline and one unknown molecule had higher relative concentration in serum at endpoint. A fiber-targeted dietary approach may be helpful in the treatment of patients with NAFLD, by changing the serum microbiota metabolome.
- Subjects
DIETARY fiber; PILOT projects; FOOD habits; LIPOPOLYSACCHARIDES; BREAD; BRANCHED chain amino acids; CLINICAL trials; GUT microbiome; METABOLOMICS; ANTHROPOMETRY; NON-alcoholic fatty liver disease; NUCLEAR magnetic resonance spectroscopy; GAS chromatography; MASS spectrometry; SHORT-chain fatty acids; METABOLITES
- Publication
Nutrients, 2022, Vol 14, Issue 24, p5355
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14245355