We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study.
- Authors
Kharaeva, Zaira; Shokarova, Albina; Shomakhova, Zalina; Ibragimova, Galina; Trakhtman, Pavel; Trakhtman, Ilya; Chung, Jessie; Mayer, Wolfgang; De Luca, Chiara; Korkina, Liudmila
- Abstract
Food supplements based on fermented Carica papaya and Morinda citrifolia, known for their immune modulating, redox balancing, and anti-inflammatory effects, were added to conventional treatment protocols prescribed to patients recovering after severe and moderate COVID-19 disease in order to alleviate long-lasting post-COVID symptoms. A randomized single-center placebo-controlled clinical laboratory study was designed and performed (total number of participants 188, with delta variant of virus 157, with omicron 31). Clinical statuses were assessed using computer tomography, electrocardiography, a questionnaire, and physical endurance. Plasma cytokines (IL-6, IL-8, IL-17A, and INF-gamma), nitrate/nitrite ratio, antioxidant activity (AOA), and polymorphonuclear leukocyte (PMN) ATP levels were determined before and 20 days following the addition of 28 g of fermented supplements twice per day. The capacity of PMN to phagocyte and the oral-nasal-pharyngeal microbiota were assessed. Clinical symptoms, IL-6, IL-8, and nitric oxide metabolites diminished significantly compared to the placebo group and their background expression. The PMN capacity to phagocyte, AOA, and ATP content remarkably increased. The oral-nasal-pharyngeal microbiota were unchanged. On these grounds, we suggest that fermented tropical fruits could efficiently diminish post-COVID clinical symptoms through several immune-modulating, redox balancing, and pro-energy mechanisms.
- Subjects
FERMENTED foods; DRUG efficacy; CYTOKINES; INTERLEUKINS; ADENOSINE triphosphate; ENERGY metabolism; MORINDA citrifolia; NITRITES; POST-acute COVID-19 syndrome; PHYSICAL fitness; NITRATES; ANTIOXIDANTS; DIETARY supplements; PAPAYA; RANDOMIZED controlled trials; INTERFERONS; NEUTROPHILS; ELECTROCARDIOGRAPHY; QUESTIONNAIRES; HUMAN microbiota; STATISTICAL sampling; COMPUTED tomography
- Publication
Nutrients, 2022, Vol 14, Issue 11, p2203
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14112203