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- Title
Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?
- Authors
Corrêa, Hugo de Luca; Alfaro-Magallanes, Víctor Manuel; Moura, Sting Ray Gouveia; Neves, Rodrigo Vanerson Passos; Deus, Lysleine Alves; Honorato, Fernando Sousa; Silva, Victor Lopes; Raab, Artur Temizio Oppelt; Maia, Beatriz Carneiro Habbema; Padula, Isabela Akaishi; Gusmão Alves, Lucas Santos de; Machado, Rafaela Araújo; Reis, Andrea Lucena; Prestes, Jonato; Ferreira, Carlos Ernesto Santos; Neto, Luiz Sinésio da Silva; Tavares, Fernanda Silveira; Andrade, Rosângela Vieira; Rosa, Thiago dos Santos
- Abstract
We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL—none; n = 19), treated only with iron sulfate or EPO (CTL—EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL—EPO + IRON; n = 76). The RT group followed the same pattern: (RT—none; n = 20), (RT—EPO or IRON; n = 18), and (RT—EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.
- Subjects
TREATMENT of chronic kidney failure; IRON metabolism; RESISTANCE training; HEMOGLOBINS; FERRITIN; INFLAMMATION; IRON; EXERCISE physiology; RANDOMIZED controlled trials; DESCRIPTIVE statistics; COMBINED modality therapy; STATISTICAL sampling; BODY mass index; ERYTHROPOIETIN; IRON compounds
- Publication
Nutrients, 2021, Vol 13, Issue 9, p3250
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13093250