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- Title
Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM-1<sup>®</sup>) Displays In Vitro Activity against Some Intestinal Pathogens.
- Authors
Ruiz, Lorena; Belén Flórez, Ana; Sánchez, Borja; Antonio Moreno-Muñoz, José; Rodriguez-Palmero, Maria; Jiménez, Jesús; de los Reyes Gavilán, Clara G.; Gueimonde, Miguel; Ruas-Madiedo, Patricia; Margolles, Abelardo
- Abstract
Certain non-digestible oligosaccharides (NDO) are specifically fermented by bifidobacteria along the human gastrointestinal tract, selectively favoring their growth and the production of health-promoting metabolites. In the present study, the ability of the probiotic strain Bifidobacterium longum subsp. infantis CECT7210 (herein referred to as B. infantis IM-1®) to utilize a large range of oligosaccharides, or a mixture of oligosaccharides, was investigated. The strain was able to utilize all prebiotics screened. However, galactooligosaccharides (GOS), and GOS-containing mixtures, effectively increased its growth to a higher extent than the other prebiotics. The best synbiotic combination was used to examine the antimicrobial activity against Escherichia coli, Cronobacter sakazakii, Listeria monocytogenes and Clostridium difficile in co-culture experiments. C. difficile was inhibited by the synbiotic, but it failed to inhibit E. coli. Moreover, Cr. sakazakii growth decreased during co-culture with B. infantis IM-1®. Furthermore, adhesion experiments using the intestinal cell line HT29 showed that the strain IM-1® was able to displace some pathogens from the enterocyte layer, especially Cr. sakazakii and Salmonella enterica, and prevented the adhesion of Cr. sakazakii and Shigella sonnei. In conclusion, a new synbiotic (probiotic strain B. infantis IM-1® and GOS) appears to be a potential effective supplement for maintaining infant health. However, further studies are needed to go more deeply into the mechanisms that allow B. infantis IM-1® to compete with enteropathogens.
- Publication
Nutrients, 2020, Vol 12, Issue 11, p1
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12113259