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- Title
Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women.
- Authors
Anderson, Sharon M.; Thurman, Andrea R.; Chandra, Neelima; Jackson, Suzanne S.; Asin, Susana; Rollenhagen, Christiane; Ghosh, Mimi; Daniels, Jason; Vann, Nikolas C.; Clark, Meredith R.; Doncel, Gustavo F.
- Abstract
While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.
- Subjects
HIV infection risk factors; FLUIDS; GENE expression; FEMALE reproductive organs; HIV; ORAL drug administration; RISK assessment; STATISTICAL sampling; VITAMIN D; VITAMIN D deficiency; PILOT projects; RANDOMIZED controlled trials; DESCRIPTIVE statistics
- Publication
Nutrients, 2020, Vol 12, Issue 10, p3176
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12103176