We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care.
- Authors
Junji Yodoi; Hai Tian; Takashi Inamoto; Yoshiyuki Matsuo; Hiroshi Masutani
- Abstract
Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies. Preclinical and clinical studies using recombinant TRX (rhTRX) are now underway. We have also identified substances that induce the expression of TRX in the body, in vegetables and other plant ingredients. Skincare products are being developed that take advantage of the anti-inflammatory and anti-allergic action of TRX. Furthermore, we are currently engaged in the highly efficient production of pure rhTRX in several plants, such as lettuce, grain and rice.
- Subjects
THERAPEUTIC use of proteins; AGING; ANTI-inflammatory agents; ANTIHISTAMINES; DERMATOLOGIC agents; GRAIN; LETTUCE; MEDICAL care; MEDICARE; OXIDATION-reduction reaction; RICE; SKIN care
- Publication
Nutrients, 2017, Vol 9, Issue 10, p1081
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu9101081