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- Title
The Challenges of Whole-Genome Approaches to Common Diseases.
- Authors
Moore, Jason H.; Ritchie, Marylyn D.
- Abstract
Offers a look at the study of the genetic contribution to common human diseases. Discussion of technological challenges that will need to be overcome to identify susceptibility genes that can be used to improve the prevention, diagnosis and treatment of common diseases; Importance of developing statistical methods to analyze genetic data; Discussion of familial versus sporadic forms of breast cancer; Problems identifying susceptibility genes from the entire human genome; Relationship between human single-nucleotide polymorphisms and disease susceptibility; Prioritization of polymorphism evaluation based on knowledge of biological function; Interpretation of gene-gene interaction models.
- Subjects
GENETIC polymorphisms; DISEASE susceptibility; HUMAN gene mapping; ETIOLOGY of diseases; GENOMES; GENOMICS; HUMAN genome; BREAST cancer
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 291, Issue 13, p1642
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.291.13.1642