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- Title
HIV-1 seroconversion in patients with and without genital ulcer disease. A prospective study.
- Authors
Telzak, Edward E.; Chiasson, Mary Ann; Bevier, Pamela J.; Stoneburner, Rand L.; Castro, Kenneth G.; Jaffe, Harold W.; Telzak, E E; Chiasson, M A; Bevier, P J; Stoneburner, R L; Castro, K G; Jaffe, H W
- Abstract
<bold>Objective: </bold>To determine the relative risk for human immunodeficiency virus (HIV-1) seroconversion in patients with and without genital ulcers caused by chancroid, syphilis, and herpes.<bold>Design: </bold>A prospective cohort study.<bold>Setting: </bold>An inner-city, sexually transmitted disease clinic.<bold>Patients: </bold>Patients seronegative for HIV-1 with and without genital ulcers who were followed for a minimum of 3 months.<bold>Interventions: </bold>Questionnaire to obtain data on demographics, sexual behavior, and illicit drug use; testing for HIV-1 at entry and at a minimum of 3 months after entry; medical examination for the presence or absence of genital ulcer disease.<bold>Results: </bold>Overall, 758 heterosexual men with no history of injection drug use completed the study; HIV-1 seroconversion occurred in 10 of 344 (2.9%; 95% CI, 1.4% to 5.3%) men with a genital ulcer and in 4 of 414 (1%; CI, 0.2% to 2.5%) without a genital ulcer (relative risk, 3.0; P = 0.05). In a multiple logistic regression analysis, those men with chancroid and a new sexually transmitted disease during follow-up each had about three times the risk for HIV-1 seroconversion (P < or = 0.04).<bold>Conclusions: </bold>In this group of heterosexual men, chancroid and repeated acquisition of sexually transmitted diseases appeared to facilitate the sexual transmission of HIV-1.
- Subjects
HIV; ULCERS; CHANCROID; SEXUALLY transmitted diseases; INFECTIOUS disease transmission; COMPARATIVE studies; FEMALE reproductive organ diseases; MALE reproductive organ diseases; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; REGRESSION analysis; RESEARCH; HUMAN sexuality; SUBSTANCE abuse; EVALUATION research; HIV seroconversion; DISEASE complications
- Publication
Annals of Internal Medicine, 1993, Vol 119, Issue 12, p1181
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-119-12-199312150-00005