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- Title
Thymoma-Associated Neuromyotonia with Antibodies against Voltage-Gated Potassium Channels Presenting as Chronic Intestinal Pseudo-Obstruction.
- Authors
x00E7;ois#Viallard, Jean-Fran&; Vincent, Angela; x00E7;ois#Moreau, Jean-Fran&; Parrens, Marie; Pellegrin, Jean-Luc; Ellie, Emmanuel
- Abstract
Chronic intestinal pseudo-obstruction can occur as a paraneoplastic disorder, and several cases have been reported in association with thymoma or small-cell lung cancer. Autoantibodies against voltage-gated potassium channels (VGKCs) are found in acquiredneuromyotonia (Isaac’s syndrome), and have been reported in one case of slow transit constipation without apparent neurological disease. We describe a patient with VGKC antibodies, acquired neuromyotonia and thymoma, who first presented with a severe slow-transit constipation and in whom the gastrointestinal symptoms responded well to plasmapheresis. We suggest that VGKC antibodies might be helpful in patients with possible paraneoplastic chronic intestinal pseudo-obstruction, and a positive result should stimulate the search for a thymoma or other tumour and raise the possibility of immunotherapy. Copyright © 2005 S. Karger AG, Basel
- Subjects
SMALL cell lung cancer; AUTOANTIBODIES; LUNG cancer; IMMUNOGLOBULINS; CONSTIPATION; IMMUNOTHERAPY
- Publication
European Neurology, 2005, Vol 53, Issue 2, p60
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000084300