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- Title
S30 - THE PROTECTİVE EFFECTS OF OMEGA-3 FATTY ACİDS ON DOXORUBİCİN-INDUCED HEPATOTOXİCİTY AND NEPHROTOXİCİTY İN RATS.
- Authors
TÜLÜBAŞ, Feti; GÜREL, Ahmet; ORAN, Mustafa; TOPÇU, Birol; ÇAĞLAR, Veli; UYGUR, Emine
- Abstract
This study aims to research the protective effect of omega (w)-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats. Twenty-four adult male Sprague-Dawley rats were divided into three groups. Group I was used as control and only saline was given by intragastric gavage. Group II received doxorubicin at the dose of 30 mg/kg intraperitoneally in 28th day. Group III was given w-3 fatty acids at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received doxorubicin at the dose of 30 mg/kg intraperitoneally in 28th day. At the end of the 30 day experimental period, the serum, liver and kidney tissue specimens taken from animals under general anesthesia. GSH and MDA levels in serum and GSH and MDA levels and SOD and GSH-PX activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels of rats given doxorubicin was observed and a significant decrease in the levels of GSH and SOD and GSH-Px activities in serum, liver and kidney tissues were determined compared with control group. In addition, a significant decrease was observed in MDA levels of rats given w-3 fatty acids with doxorubicin and a significant increase was determined in the levels of GSH and SOD and GSH-Px activities in serum, liver and kidney tissues, compared with doxorubicin group. We concluded that w-3 fatty acid had favorable effects in rat liver and kidney tissues by preventing oxidative damage.
- Subjects
OMEGA-3 fatty acids; DOXORUBICIN; HEPATOTOXICOLOGY
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p132
- ISSN
0250-4685
- Publication type
Abstract