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- Title
Investigating the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis in patients with head-and-neck cancer.
- Authors
Najafizade, Nadia; Dehkordi, Roya Mobini; Hemati, Simin
- Abstract
Background: Oral mucositis is one of the main complications of radiotherapy (RT) while treating head-and-neck cancers and can affect the patients' treatment process and life. Therefore, this study evaluated the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis (RIOM) in patients with head-and-neck cancer. Materials and Methods: This was a double-blind clinical trial performed in 2019 on 75 patients with head-and-neck cancer. Patients were randomly assigned to two groups receiving gargles of 5 cc Aloe vera and the same dose of placebo mouthwash three times a day, respectively. Then, the incidence and severity of RIOM were evaluated and compared between the two groups over 6 weeks of RT. Results: There was no significant difference between the two groups in terms of the severity of RIOM from the 1st to 3rd weeks of RT (P > 0.05). However, the severity of RIOM in the 4th, 5th, and 6th weeks of RT was significantly lower in the Aloe vera group compared with the placebo group (P < 0.05). Conclusion: According to the results of the present study, the long-term use of Aloe vera mouthwash can reduce the severity of RIOM.
- Subjects
STOMATITIS treatment; STOMATITIS; ALOE; MUCOSITIS; RADIOTHERAPY; RESEARCH funding; HEAD &; neck cancer; BLIND experiment; STATISTICAL sampling; SEX distribution; SMOKING; TREATMENT effectiveness; RANDOMIZED controlled trials; SEVERITY of illness index; TREATMENT duration; DESCRIPTIVE statistics; AGE distribution; COMPARATIVE studies; MOUTHWASHES; EVALUATION
- Publication
Journal of Research in Medical Sciences, 2024, Vol 29, p1
- ISSN
1735-1995
- Publication type
Article
- DOI
10.4103/jrms.jrms_115_23